Close-up of a brain slice showing two large intraparenchymal haemorrhages (one of the partially organized). Hypertension is the most frequent cause of this type of stroke.

Close-up of a gross specimen showing the surface of a human kidney in a case of autosomal dominant polycystic kidney disease (ADPKD). The surface is full of large cysts. ADPKD is caused by mutations in PKD genes that produce a specific abnormal protein that has an adverse effect on tubule development.

Gross specimen showing two brain slices of the frontal lobe showing an intraparenchymal haemorrhage. Hypertension is the most frequent cause of this type of stroke.

Coronal section through a human brain at the thalamus level showing a large abscess, probably of bacterial origin, located in the temporal lobe. The growth of the abscess produces a deviation of the lateral ventricle.

Low power light microscope micrograph of a human submandibular or submaxillary gland. This is a mixed salivary gland with predominance of serous acini. The PAS stain highlights the mucous component of the mixed tubule acini.

Human spleen. Lymphoid follicle, a component of white pulp. On top, a periarteriolar lymphoid sheath, another component of white pulp. The rest of micrograph is the red pulp, composed by splenic sinusoids and cord of Billroth showing macrophages with iron pigment

Human liver. Cirrhosis. Low magnification micrograph showing regenerating nodules of hepatocytes (with an extensive fatty change), separated by fibrous septa with chronic inflammatory infiltrates. Cirrhosis of the liver is a result of severe damage to the liver. The hard scar tissue that replaces healthy liver tissue. Cirrhosis can lead to liver failure and liver cancer.

High magnification TEM micrograph of the nucleolus of a hepatocyte showing the dense fibrillar component and the granular component.

Human aorta. Dissecting aneurysm or aortic dissection. Low magnification micrograph showing a dissecting aneurysm located in the middle layer of the aorta wall. Macrophages loaded with iron pigment appear in the detachment zone.

Large-bowel adenocarcinoma. Cancer cells arranged in cords or strands with empty central spaces remembering the normal crypts of the colon mucosa.

Liver. Erythroblastosis fetalis is characterized by intravascular proliferation of immature precursors of erythrocytes. Histologically, accumulation of erythroblasts in blood sinusoids is observed

Low magnification micrograph of a seminoma, a germ cell malignant tumor of the testicle. The micrograph shows a lobular pattern of clear cancerous cells with a fibrous stromal network.

Human fallopian tube affected by chronic salpingitis. The fallopian tube lumen is enlarged, the mucosal folds widened and shortened, and the lamina propria shows chronic inflammatory infiltrates.

Transmission electron micrograph (TEM) showing two desmosomes (maculae adherentes) with prominent dense plaques where keratin intermediate filaments were attached.

Crypts of large bowel mucosa in cross section showing the abundance of goblet cells. The lamina propria shows many lymphocytes.

Human lung affected by an acute bronchopneumonia, commonly a hospital-acquired bacterial pneumonia. The lumen of alveoli is occupied by liquid of oedema which contains acute inflammatory infiltrates (with predominance of neutrophil granulocytes). On the right, a bronchus filled with pus.

Periphery of a human lung affected by an acute pneumonia. The lumen of alveoli is occupied by liquid of oedema which contains acute inflammatory infiltrates (with predominance of neutrophil granulocytes). On the right, the pleura shows many carbon-loaded macrophages.

Human liver. Micronodular cirrhosis. Regenerating nodule of hepatocytes showing an extensive fatty change (steatosis), separated by fibrous septa with chronic inflammatory infiltrates.

Transmission electron micrograph (TEM) showing a desmosome (macula adherens) with prominent dense plaques where keratin intermediate filaments were attached.

Kidney cortex. Two renal corpuscles surrounded by cancer cells of lymphosarcoma metastasis that invade the renal cortex.

TEM micrograph showing hepatocyte plates located among three sinusoids. The hepatocyte cytoplasm shows many mitochondria and elongated cisterns of rough endoplasmic reticulum (RER). The liver sinusoids with discontinuous endothelium are surrounded by the space of Disse, full of hepatocyte microvilli

Human fallopian tube affected by chronic salpingitis. The mucosal folds are widened and shortened, and the lamina propria shows chronic inflammatory infiltrates.

Human lung affected by an acute pneumonia. The lumen of alveoli is occupied by liquid of oedema which contains acute inflammatory infiltrates (with predominance of neutrophil granulocytes).

Light microscope micrograph of a seminoma, a germ cell malignant tumor of the testicle. The micrograph shows sheets of clear cancerous cells with a fibrous stromal network. Darker areas are chronic inflammatory infiltrates.

High magnification TEM micrograph of the nucleolus of a hepatocyte showing the dense fibrillar component and the granular component. The nucleolus is surrounded by dark nucleolus associated chromatin

isogenous groups. The cells of hyaline cartilaginous tissue (chondrocytes) undergo mitosis to form an isogenous group surrounded by a basophilic halo.

High magnification TEM micrograph showing the nucleolus of a hepatocyte surrounded by dark nucleolus associated chromatin

TEM micrograph showing a binucleated hepatocyte. The cytoplasm shows many mitochondria and elongated cisterns of rough endoplasmic reticulum (RER). In three micrograph corners, the space of Disse with many microvilli can be seen

Most of spleen parenchyma is the red pulp, composed by splenic sinusoids and cords of Billroth showing macrophages with iron pigment. On bottom, a periarteriolar lymphoid sheath a component of white pulp.

Human blood smear showing a lymphocyte at bottom and an erythroblast (normoblast) on top.

Human blood smear showing a lymphocyte. The small bluish dots among the red blood cells are platelets.

Human blood smear. Leukocytosis in an acute infection. Neutrophil leukocyte with nuclear hypersegmentation.

Human blood smear. Leukocytosis in an acute infection. Neutrophil leukocyte with nuclear hypersegmentation. Platelets are also seen among red blood cells.

Human blood smear, where a lymphocyte with cytoplasmic granules is observed. The small bluish dots among the red blood cells are platelets. There are many crenated red blood cells.

Human blood smear, where a lymphocyte is observed. The small bluish dots among the red blood cells are platelets.

Human blood smear, where a neutrophil leukocyte with toxic granulations is observed. The small bluish dots among the red blood cells are platelets.

Human blood smear, where an immature neutrophil leukocyte (band cell) with toxic granulations is observed. The small bluish dots among the red blood cells are platelets.

Human blood smear. Leukocytosis in an acute infection. Neutrophil leukocytes exhibit nuclear hypersegmentation and toxic granules in the cytoplasm. Platelets are also seen among red blood cells.

Human blood smear, with platelets among the red blood.

Human blood smear. Leukocytosis in an acute infection. Neutrophil leukocytes with nuclear hypersegmentation.

Human blood smear showing a neutrophil leukocyte. The small bluish dots among the red blood cells are platelets.

Human blood smear showing a monocyte. The small bluish dots among the red blood cells are platelets.

Human blood smear showing a monocyte (up) with toxic granules and a lymphocyte (down).

Human blood smear, where an eosinophil is observed.

Human blood smear. Leukocytosis in an acute infection. Most of the neutrophil leukocytes exhibit nuclear hypersegmentation.

Human blood smear showing a monocyte leukocyte with some granules in its cytoplasm in an infectious mononucleosis. The small bluish dots between the red blood cells are platelets.

Human blood smear showing a neutrophil leukocyte with a polylobulated banded nucleus (up) and another with a polylobulated nucleus (down). The small bluish dots among the red blood cells are platelets.

Human blood smear showing a neutrophil leukocyte (up) and a lymphocyte (down). The small bluish dots among the red blood cells are platelets.

Human blood smear showing two lymphocytes.

Human blood smear showing a neutrophil with ring-shaped nucleus and toxic granulations in their cytoplasm in an infectious mononucleosis. The small bluish dots among the red blood cells are platelets.

Human blood smear showing a monocyte (center) and a lymphocyte (right). The small bluish dots among the red blood cells are platelets.

Human blood smear showing a lymphocyte with granules in its cytoplasm in an infectious mononucleosis. The small bluish dots among the red blood cells are platelets.

Human blood smear showing a neutrophil (left) and a monocyte (right). The small bluish dots between the red blood cells are platelets.

Human blood smear showing a neutrophil with toxic granulations in its cytoplasm in an infectious mononucleosis.

Human blood smear showing an eosinophil leukocyte, with abundant red granules and a characteristic bilobed nucleus.

Human blood smear showing a monocyte leukocyte, with a lobulated nucleus. It is the largest leukocyte (compare with red blood cell size).

Human blood smear showing a reactive lymphocyte with granules in its cytoplasm in an infectious mononucleosis. The small bluish dots among the red blood cells are platelets.

Human blood smear showing a monocyte with a basophilic cytoplasm in an infectious mononucleosis. It is the largest leukocyte (compare with red blood cell size).

The interstitial or Leydig cells secrete testosterone, the male sex hormone. They are polyhedral epithelioid cells with a single round nucleus and an acidophilic cytoplasm which contains pigment granules and lipid droplets.

Cross section of a human fallopian tube. The innermost layer is a very folded mucosa. Outside are located the muscular layer and the serosa layer, showing abundant blood vessels, Light micrograph.

Bundles of collagen fibers in a connective tissue stained with a silver method.  The collagen fibers show a typical wavy appearance.

Low magnification micrograph showing a human thyroid. The thyroid parenchyma is composed by many follicle filled with colloid. Light microscope micrograph. Hematoxylin & eosin stain

False colour transmission electron microscope (TEM) micrograph showing the cytoplasm of a protein-synthetizing cell packed with parallel cisterns of rough endoplasmic reticulum. The lumen of cisternae is labelled in blue colour and the cytoplasm, full of ribosomes, is labelled in green color.

Kaba endoplazmik retikulumun paralel sarnıçları ile paketlenmiş protein sentezleyen bir hücrenin sitoplazmasını gösteren yanlış renk iletimli elektron mikroskobu (TEM) mikrografı Sarnıçların lümeni mavi renkle etiketlenir ve ribozomlarla dolu sitoplazma yeşil renkle etiketlenir.

Low magnification micrograph of a human submandibular gland, stained with hematoxylin-eosin. The parenchyma show many lobules and large secretory ducts.

Group of neurons in the central nervous system, stained with cresyl violet. In each neuron, a Barr body (sex chromatin) is located near to the nucleolus. Light microscope micrograph.

Endometrium. Advanced secretory or luteal phase, near menstruation. Endometrial glands appear dilated and with irregular contour. The uterine stroma appear loose and oedematous.

False colour transmission electron microscope (TEM) micrograph of an oogonium showing the nucleus (green), the nuclear envelope (pink) and an atypical nucleolus (dark blue). In the cytoplasm (light blue), there are mitochondria (red) and lipid droplets (yellow).

Çekirdeği (yeşil), nükleer zarfı (pembe) ve atipik bir nükleolü (koyu mavi) gösteren bir oogonyumun yanlış renk geçirimli elektron mikroskobu (TEM) mikrografı. Sitoplazmada (açık mavi) mitokondri (kırmızı) ve lipid damlacıkları (sarı) vardır.

Neuron stained with cresyl violet showing a Barr body (sex chromatin) located near to a big nucleolus. Light microscope micrograph.

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Jose Calvo

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